The _XSETTING_S[N] selection is managed as a manager selection according to section 2.8 of the ICCCM and the handling of the selections window, the _XSETTING_S[N] window and MANAGER client messages must conform to that specification.
The settings manager changes the contents of the _XSETTINGS_SETTINGS property of the root window whenever the source it derives them from changes, taking care to increment the 'serial' field at each increment and set the 'last-change-serial' fields appropriately.